Erwin 2020

A Sparse, Spatially Biased Subtype of Mature Granule Cell Dominates Recruitment in Hippocampal-Associated Behaviors

https://www.cell.com/cell-reports/pdf/S2211-1247(20)30461-7.pdf

JC 6/15/20 Elif

In Brief

Erwin et al. identify a sparse subtype of mature granule cell, spatially localized within the dentate gyrus, which dominates overall granule cell activity across a range of behavioral paradigms. Thus, subtype-specific heterogeneity exists and predicts cellular recruitment at the first stage of hippocampal processing.

Highlights

d Mature granule cells of the dentate gyrus exist in discretely separable subtypes

d Subtype prevalence and cellular activity covary across dentate gyrus blades

d Active cells exhibit specialized morphology, physiology, and birthdates

d Penk expression marks atypical, preferentially recruited granule cell subtype

Notes

Cell division is defined in groups, eg in DG and pyramidal cells of CA3, CA1

More recently, even in broad regions, there are different cell types. Cembrowski 2019

Little is knwn about subtye specific decomposition of mature granule cells, although they particiate in memory engrams (Hainmueller 2020) 2 photon microscopy on mouse, to show place cells. Discrimination. Previous work shows that blade specific recruitment may relate to function.

Fig 1. Granule ells of the suprapyramidal blade of the dentate gyrus are preferentially activated across a range of behavioral paradigms.(footshock, novel odor, novel object, conspecific, forced swim. All more activity in suprapyramidal (dorsal) blade than infra (ventral)

weakness: ventral isn't necessarily the same as infrapyramidal. also seem to look at more caudal sections. only 3 mice per group.

neurons might be of different ages. Only prox 1 and pcp4 staining, in supplement, slc7 neuron marker. Also RNA seq data on age of neurons.

timing of cre may not associate with behavior. how well are the labeled neurons correlated with the behavior tested?

Fig 3 birthdating (E15, E17)

Williams et al semilunar granule cells 2007